Clinical study of solid dispersions of prepared by double stage extrusion (3)

Due to high variability, a significant decrease in AUC and Cmax was only observed for the Eudragit E100-PVPVA formulation. Although the solid dispersions showed different in vitro dissolution behavior and double stage extrusion, Tmax values were comparable. The same observations with respect to AUC, Cmax and Tmax could be made for hydroxyitraconazole. The present results indicate that hot-stage extrusion can be considered as a valuable alternative for manufacturing solid dispersions of itraconazole.